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ImmunoQs
Research

Two fields.
One shared question.

What can we understand when we see biology differently?

ImmunoQs grew from two ways of seeing biology. One found patterns through computation, imaging and machine learning. The other found meaning through immunology, pathology and spatial biology.

Different disciplines. Same curiosity. The interesting part happened where they met.

Two PIs, two perspectives
Lit Hsin's lab at A*STAR

Lit Hsin Loo, PhD

Seeing patterns at scale.
Computational biology Machine learning Image-based phenotyping

His research uses imaging, computation and machine learning to find patterns at scale, turning complex biological data into measurable insights about how cells behave.

Joe's lab at A*STAR

Joe Yeong, PhD, FRCPath (UK)

Seeing biology in context.
Immunology Pathology Spatial biology

His research looks at where cells are, who they're interacting with, and what those relationships reveal about disease.

Where the two meet

Two ways of seeing biology.
Much more interesting together.

One taught machines to find patterns. The other learned to read them in tissue. ImmunoQs grew where the two met.

See what we built →
One side brought
Machine learningImagingQuantitative analysis
+
The other brought
ImmunologyPathologySpatial biology
From their labs

The science behind us, published.

14 featured papers
Featured Publication
Field
Cell Press Blue · Aug 2026

Spatial multiomics approaches for antibody-drug conjugate target discovery

10.1016/j.cpblue.2026.100085 →
Spatial Multiomics
Cancer Discovery · Aug 2026

Same-Slide Spatial Multiomics Integration with IN-DEPTH Reveals Tumor Virus–Linked Spatial Reorganization of the Tumor Microenvironment

10.1158/2159-8290.CD-25-0775 →
Spatial Multiomics
Journal of Clinical Oncology · May 2026

Clinical outcomes in phase 1 study of EBC-129, a first-in-class, anti-N256-glycosylated CEACAM5 and CEACAM6 ADC, in patients with gastroesophageal adenocarcinomas

10.1200/JCO.2026.44.16_suppl.3033 →
Clinical Oncology
Molecular Systems Biology · Apr 2026

Spatially-guided metabolomics profiling of metabolic regions in human tumor tissues

10.1038/s44320-026-00205-w →
Spatial Metabolomics
JHEP Reports · Feb 2026

Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence

10.1016/j.jhepr.2026.101790 →
Spatial Transcriptomics
Genomics, Proteomics & Bioinformatics · Jan 2026

FAST: Scalable Factor Analysis for Spatial Dimension Reduction of Multi-section Spatial Transcriptomics

10.1093/gpbjnl/qzag006 →
Bioinformatics
Advanced Science · Nov 2025

Single-Cell Profiling: Any Scale, Any Size, All at Once

10.1002/advs.202518479 →
Single-Cell Biology
Journal of Genetics and Genomics · Sep 2025

The application and prospects of spatial omics technologies in clinical medical research and molecular diagnostics

10.1016/j.jgg.2025.09.003 →
Spatial Omics
Frontiers in Molecular Biosciences · Jul 2025

An integrated approach for analyzing spatially resolved multi-omics datasets from the same tissue section

10.3389/fmolb.2025.1614288 →
Spatial Multiomics
Preprint · Jun 2025

A Foundation Model for Spatial Proteomics

10.48550/arXiv.2506.03373 →
AI / Spatial Proteomics
Nature · Mar 2025

Spatial immune scoring system predicts hepatocellular carcinoma recurrence

10.1038/s41586-025-08668-x →
Spatial Immunology
Current Opinion in Biotechnology · Mar 2024

Spatial omics techniques and data analysis for cancer immunotherapy applications

10.1016/j.copbio.2024.103111 →
Spatial Omics
Gastric Cancer · Jun 2022

Choice of PD-L1 immunohistochemistry assay influences clinical eligibility for gastric cancer immunotherapy

10.1007/s10120-022-01301-0 →
Immuno-Oncology
Advanced Drug Delivery Reviews · Sep 2021

Leveraging advances in immunopathology and artificial intelligence to analyze in vitro tumor models in composition and space

10.1016/j.addr.2021.113959 →
AI / Digital Pathology

These papers are the work of independent academic labs at A*STAR. They are listed here to show the scientific lineage behind ImmunoQs, not as ImmunoQs publications. For work carried out on our platform, see Publications.